A Thomas Look Selected Research

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)

11/2022	Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.
1/2021	Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).
1/2018	JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
11/2017	TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.
1/2017	Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.
12/2016	Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
1/2015	Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.
12/2014	Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
11/2014	Cyclin C is a haploinsufficient tumour suppressor.
2/2014	c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.

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A Thomas Look Research Topics

Disease

56	Neoplasms (Cancer) 01/2022 - 08/2003
35	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 11/2022 - 07/2003
28	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2022 - 03/2004
22	Neuroblastoma 10/2021 - 12/2005
21	Leukemia 11/2022 - 10/2002
6	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2012 - 07/2004
5	Carcinogenesis 01/2020 - 02/2003
4	Ganglioneuroma 01/2021 - 10/2009
4	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 09/2011
4	Genetic Translocation (Chromosomal Translocation) 01/2019 - 01/2005
3	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2021 - 03/2009
3	Adenocarcinoma 01/2020 - 10/2014
3	Neurofibrosarcoma (MPNST) 01/2019 - 12/2010
3	Lymphoma (Lymphomas) 01/2019 - 06/2007
3	T-Cell Leukemia (Leukemia, T Cell) 01/2014 - 03/2004
3	Ataxia Telangiectasia (Louis Bar Syndrome) 03/2012 - 05/2008
3	Inflammation (Inflammations) 08/2009 - 12/2006
2	Melanoma (Melanoma, Malignant) 01/2021 - 02/2005
2	Glioma (Gliomas) 01/2019 - 12/2010
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 11/2014 - 09/2012
2	Chromosome 5q Deletion Syndrome 11/2014 - 11/2012
2	Ganglioneuroblastoma 03/2013 - 10/2009
2	Carcinoma (Carcinomatosis) 10/2012 - 03/2008
2	Glioblastoma (Glioblastoma Multiforme) 12/2010 - 03/2009
2	Wounds and Injuries (Trauma) 06/2009 - 08/2008
2	Acute Promyelocytic Leukemia 06/2007 - 04/2004
1	T-Cell Lymphoma (Lymphoma, T Cell) 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2021
1	alpha-Thalassemia 01/2019
1	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm) 01/2019

Drug/Important Bio-Agent (IBA)

22	Proteins (Proteins, Gene)FDA Link 11/2022 - 08/2003
16	Transcription Factors (Transcription Factor)IBA 10/2021 - 03/2004
14	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 12/2004
10	Phosphotransferases (Kinase)IBA 01/2020 - 11/2005
9	Biological ProductsIBA 01/2017 - 10/2003
7	Pharmaceutical PreparationsIBA 01/2020 - 02/2003
5	Biomarkers (Surrogate Marker)IBA 11/2022 - 11/2005
5	EnzymesIBA 01/2022 - 02/2007
5	Gamma Secretase Inhibitors and ModulatorsIBA 03/2010 - 02/2007
4	Adrenergic Agents (Adrenergic Drugs)IBA 10/2021 - 12/2019
4	Sirolimus (Rapamycin)FDA Link 01/2021 - 09/2012
4	N-Myc Proto-Oncogene ProteinIBA 01/2021 - 03/2013
4	Anaplastic Lymphoma KinaseIBA 01/2021 - 03/2009
4	RNA (Ribonucleic Acid)IBA 01/2019 - 04/2005
4	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2017 - 08/2008
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2016 - 07/2004
4	Messenger RNA (mRNA)IBA 08/2011 - 03/2004
3	Histones (Histone)IBA 10/2021 - 01/2007
3	MTOR InhibitorsIBA 01/2021 - 10/2020
3	ChromatinIBA 01/2020 - 01/2018
3	Tyrosine (L-Tyrosine)FDA Link 01/2019 - 11/2005
3	Small Interfering RNA (siRNA)IBA 01/2018 - 10/2008
3	Ribosomal Proteins (Ribosomal Protein)IBA 11/2014 - 09/2012
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2014 - 05/2006
3	Neurofibromin 1 (Neurofibromin)IBA 11/2012 - 12/2009
3	Notch ReceptorsIBA 04/2009 - 06/2007
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 04/2009 - 01/2006
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 10/2021 - 06/2007
2	RetinoidsIBA 10/2021 - 01/2016
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021 - 02/2005
2	Drug CombinationsIBA 01/2021 - 01/2019
2	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2020 - 12/2016
2	GenieIBA 01/2020 - 01/2019
2	MicroRNAs (MicroRNA)IBA 01/2020 - 04/2011
2	Basic-Leucine Zipper Transcription FactorsIBA 01/2018 - 06/2005
2	ElementsIBA 01/2018 - 12/2015
2	Oncogene Proteins (Oncogene Protein)IBA 12/2016 - 10/2002
2	Interleukin-7 (Interleukin 7)IBA 01/2015 - 03/2004
2	Leucine (L-Leucine)FDA Link 11/2014 - 09/2012
2	T-Cell Acute Lymphocytic Leukemia Protein 1IBA 07/2013 - 08/2012
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2013 - 11/2005
2	LigandsIBA 07/2012 - 03/2009
2	NucleophosminIBA 04/2010 - 03/2009
2	CytokinesIBA 01/2010 - 04/2004
2	alpha Catenin (alpha E-Catenin)IBA 01/2007 - 01/2005
1	Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA 11/2022
1	Asparaginase (Elspar)FDA Link 11/2022
1	hydrogen sulfite (bisulfite)IBA 11/2022
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2021
1	temsirolimus FDA Link 01/2021
1	NAD (NADH)IBA 01/2021
1	Everolimus FDA Link 01/2021
1	dihydrolipoamideIBA 01/2021
1	IACS-010759IBA 01/2021
1	Glutamine (L-Glutamine)FDA Link 01/2021
1	Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)IBA 01/2020
1	HoloenzymesIBA 01/2020
1	Doublecortin-Like KinasesIBA 01/2020
1	nelarabine (506U78)FDA Link 10/2019
1	alpha-GlobinsIBA 01/2019
1	Polycomb Repressive Complex 2IBA 01/2019
1	S63845IBA 01/2019
1	venetoclaxIBA 01/2019
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2019
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 01/2019
1	SteroidsIBA 01/2018

Therapy/Procedure

32	Therapeutics 11/2022 - 07/2003
10	Drug Therapy (Chemotherapy) 11/2022 - 12/2004
2	Transplantation 01/2012 - 09/2004
1	Breast Implants (Breast Implant) 01/2021